The Carr lab aims to understand how dysregulation of hepatic metabolism promotes liver disease. Our current projects involve investigating the role of lipid metabolites and lipid droplet proteins in impairing hepatic insulin signaling, a key event in the earliest stage of several metabolic liver diseases. Our lab combines molecular biology techniques, genetic models, and comprehensive in vivo physiologic studies to uncover the pathophysiologic basis of metabolic liver diseases. Studies performed in the lab form the basis for translational studies investigating the prognostic and pathologic role of lipids and lipid associated proteins.
Our current projects include alcoholic and non-alcoholic fatty liver disease models