Principal Investigator Rotonya M. Carr, M.D.
Jason Correnti, Ph.D.
Postdoctoral Research Fellow
Dr. Correnti enjoys alcoholic beverages in moderation, spurring interest in how alcohol affects liver normal function. In particular, he is interested in the observation that while many people enjoy alcohol, relatively few develop alcoholic liver disease (ALD). The goal of Dr. Correnti’s research is to understand what factors in addition to alcohol consumption separate these two groups, and is currently focused on dietary factors. The first clinical sign of ALD is the accumulation of fat in the liver, and he is studying how alcohol and dietary factors interact to alter normal liver metabolism and promote disease. The goal of these studies is to develop therapies to block ALD onset. Dr. Correnti is also a lifelong Philadelphia resident, obtaining his Ph.D. at Thomas Jefferson University, and maintains a love/hate relationship with the local pro sports teams.
Amanke Oranu, M.D.
Dr. Oranu grew up in Nigeria and attended the University of Nigeria Nsukka, one of the premier medical schools in the country. He completed his internship and residency training in internal medicine at Meharry Medical College before doing a 4-year postdoctoral research fellowship at Brigham and Women’s Hospital (BWH), a Harvard Medical School affiliate. He was appointed as an instructor and worked as internist at BWH and Faulkner hospital.
In 2014 Dr. Oranu joined the gastroenterology fellowship program at the Hospital at University of Pennsylvania. After completing 1 year of intensive clinical rotation, his next 2 years have protected time in research. Since joining Dr. Carr’s lab, he has focused on alcoholic fatty liver disease (ALD). ALD is the second most common etiology of chronic liver disease in the United States, and accounts for 44% of all liver related deaths in the United States. Dr. Oranu hopes that understanding the co-factors of ALD may provide novel targets for both prevention of ALD progression and identification of patients at risk of developing advanced disease.